-
Correlation of Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers with serum GDF-15 in a group of hypertensive Iraqi patients
-
The Growth Differentiation Factor -15 (GDF-15) is a member of the transforming growth factor ß superfamily. It represents an example of the stress response cytokines. It's mostly found in cardiac myocytes, adipocytes, macrophages, endothelial cells, and vascular endothelial cells, whether they're generated normally or not. GDF-15 levels have increased and are associated with cardiovascular risk. Aim of the study: To investigate the correlation between angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) with the level of plasma GDF-15 in a group of hypertensive patients. Materials and methods: A case-control study involved 90 individuals, 60 hypertensive patients (36 on ACE inhibitors and 24 on ARBs) and 30 healthy individuals. Serum GDF-15 was measured and compared statistically between the two groups. Results: serum GDF-15 was significantly higher in both groups of hypertensive patients compared to the control group. In addition, there was no significant difference in mean serum GDF-15 concentration between patients treated with ACE inhibitors with those treated with angiotensin II receptor blockers. Conclusion: GDF-15 increases in hypertensive patients and might be a reasonable marker of cardiovascular disease. Both ACE inhibitors and ARBs are not powerful enough to decrease GDF-15 concentration to that of the control group.
-
PDF
-
Citrus aurantium L.PEELS AND SEEDS : PHYTOCHEMICAL SCREENING AND ANTIBA CTERIAL ACTIVITY
-
أ.م.د. قتيبة ابراهيم خضر الزند2024
-
An overview of neuro-ophthalmic disorders at Jenna Ophthalmic Center, Baghdad, Iraq (2021-2022)
-
م.د ليث غضنفر شريف جمعة2024
-
Emerging Innovations In vincristine-encapsulated nanoparticles :pioneering a new era in oncological therapeutics
-
ا.م.د. اسراء غازي جبار اللعيبي الماذي2024
-
Recent advancements in irinotecan-loaded nanomaterials as a smart drug delivery system for cancer therapy : a state-of-art-review
-
ا.م.د. اسراء غازي جبار اللعيبي الماذي2024
-
Comparative Study for Citrus Fruits Peel Extract , Phytochemical Screening and In-vitro Antioxidant Activity
-
أ. م. د. ايهاب ابراهيم عبد الوهاب سليمان الخليفة2023